بررسی رفتار رهایش دارو از هیدروژل‌های هیبریدی برپایۀ پلیمرهای زیستی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دورۀ دکتری، گروه علوم و صنایع چوب و کاغذ، دانشکدۀ منابع طبیعی دانشگاه تهران، کرج، ایران

2 استاد، گروه علوم و صنایع چوب و کاغذ، دانشکدۀ منابع طبیعی دانشگاه تهران، کرج، ایران

3 دانشیار، گروه علوم و صنایع چوب و کاغذ، دانشکدۀ منابع طبیعی دانشگاه تهران، کرج، ایران

10.22059/jfwp.2022.351450.1226

چکیده

در این پژوهش هیدروژل‌های هیبریدی مؤثر به‌عنوان بن‌سازۀ تحویل دارو با استفاده از لیگنین، به‌عنوان نوعی پلیمر زیستی  حاصل از صنعت کاغذسازی قلیایی، و کیتوزان با استفاده از گلوتارالدئید به‌عنوان عامل اتصال‌دهندة عرضی تولید شدند. مقدار لیگنین فاکتور متغیر مهم این پژوهش بود و اثر آن بر مورفولوژی و خواص مکانیکی هیدروژل‌ها بررسی شد. سپس ویژگی‌های هیدروژل‌های کیتوزان تنها و کیتوزان/ لیگنین با مقادیر مختلف لیگنین با استفاده از آزمون فشار، اندازه‌گیری درصد تورم، رهایش دارو، زمان تخریب (به‌عنوان شاخصی برای ماندگاری) و ریزنگار الکترونی روبشی (SEM) بررسی شد. همچنین داروی پاراسیتامول به‌عنوان مدل دارو انتخاب و رهایش آن بررسی شد. نتایج نشان داد که اتصال‌دهندة گلوتارالدئید  می‌تواند به‌طور مؤثر ساختار شبکه‌ای ایجاد کند، چنانکه دوام و پایداری نمونه‌ها در شرایط مطلوب تا 15 روز برای نمونۀ کیتوزان خالص و 11 روز برای نمونۀ کیتوزان/ لیگنین به‌دست آمد. با این‌حال، کمترین زمان ماندگاری (5 روز) مربوط به هیدروژل با بیشترین مقدار لیگنین  بود که زمان کافی برای آزاد شدن کامل دارو بود. نتایج نشان داد که اگرچه با افزایش درصد لیگنین ساختار هیدروژل ضعیف می‌شود، با افزایش آن، رهایش دارو با سرعت بیشتری انجام می‌گیرد که می‌توان آن را عامل تغییر مقدار رهایش دارو با توجه به کاربرد مدنظر به‌شمار آورد. بیشترین مقدار رهایش در هیدروژل‌های با بیشترین مقدار لیگنین مشاهده شد، به‌طوری که در دو ساعت اول، مقدار آن حدود شش برابر بیشتر از هیدروژل کیتوزان خالص بود.

کلیدواژه‌ها

عنوان مقاله [English]

Drug release behavior of hybrid hydrogels based on biopolymers

نویسندگان [English]

  • Elahe Chiani 1
  • Yahya Hamzeh 2
  • Mohammad Azadfallah 3
1 Ph.D. Student, Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, I.R. Iran.
2 Prof., Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, I.R. Iran.
3 Assoc., Prof., Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, I.R. Iran.
چکیده [English]

In this study, efficient hybrid hydrogels as drug delivery platforms were synthesized using Kraft lignin, a biopolymer obtained from the alkaline paper industry, chitosan and glutaraldehyde as a crosslinker. The ratio of lignin was an important variable factor of this study and its effect on morphology and mechanical properties were studied. The characteristics such as compressive property, swelling capacity, drug release, degradation time, and SEM imaging of the hydrogels of chitosan and chitosan/ lignin with different amount of lignin were investigated. Also, paracetamol drug was selected as a drug model. The results showed that the glutaraldehyde crosslinker can effectively create a crosslinked structure, so that the durability and stability of the hydrogels in the desired conditions is up to 15 days for the pure chitosan sample and 11 days for the lignin chitosan sample, respectively. Although the shortest shelf life (5 days) corresponds to the highest amount of lignin, which was a shorter period of time, but it gives enough time for the drug to be completely released. The results showed that although the hydrogel structure is weakened by increasing the percentage of lignin, the drug was released faster with the increasing of lignin, which can be considered as a factor for changing the release rate of drug according to the intended application. The highest amount of release was observed in hydrogels with the highest amount of lignin, so that in the first two hours, its amount was about six times higher than that of pure chitosan hydrogel.

کلیدواژه‌ها [English]

  • hydrogel
  • lignin
  • chitosan
  • drug release
  • Paracetamol

مراجع

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نشریه جنگل و فرآورده های چوب
دوره 75، شماره 4
اسفند 1401
صفحه 387-395

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